Effect of testosterone treatment onadipokines and gut hormones in obese men on a hypocaloric diet

MNT Fui; R Hoermann; M Grossmann

Journal article

Effect of testosterone treatment onadipokines and gut hormones in obese men on a hypocaloric diet

MNT Fui, R Hoermann, M Grossmann

Journal of the Endocrine Society | ENDOCRINE SOC | Published : 2017

DOI: 10.1210/js.2017-00062

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Abstract

Context: In obese men with lowered testosterone levels, testosterone treatment augments dietassociated loss of body fat. Objective: We hypothesized that testosterone treatment modulates circulating concentrations of hormonal mediators of fat mass and energy homeostasis in obese men undergoing a weight loss program. Design: Prespecified secondary analysis of a randomized, double-blind, placebo-controlled trial. Setting: Tertiary referral center. Participants: Obese men (body mass index ≥30 kg/m2) with a repeated total testosterone level ≤12 nmol/L. Intervention: One hundred participants mean age 53 years (interquartile range 47 to 60 years) receiving 10 weeks of a very low-energy diet followe..

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University of Melbourne Researchers

Mathis Grossmann Author

Mark Ng Tang Fui Author

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Grants

Awarded by National Health and Medical Research Council, Australia

Funding Acknowledgements

M.G. was supported by a career development fellowship (1024139), and M.N.T.F. was supported by a postgraduate scholarship (1055305), both from the National Health and Medical Research Council, Australia. Bayer Pharma AG (Berlin, Germany) provided testosterone, placebo, and financial support to conduct investigations but had no role in trial design, data analysis, or writing of the manuscript.